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CorNeat KPro
A Novel Solution for Corneal Replacement Therapy
The CorNeat KPro is a patented synthetic cornea that provides a lasting solution for corneal blindness. It enables immediate vision rehabilitation after a straightforward implantation procedure. The device wide aperture lens integrates seamlessly with the eyewall using a skirt made from our EverMatrix™ tissue-integrating technology, eliminating the need for donor tissue. CorNeat KPro provides an aesthetic solution with optical performance equivalent to an ideal cornea, offering new hope for millions with cornea-related visual impairments.
A CorNEat KPro fully integrated into a patient's eye. Patient's vision improved from "hand movement" to 6/4.8 (20/16) which is better than normal vision
Implantation Procedures
Implantation Animation
The CorNeat KPro implantation procedure is relatively straightforward and does not require the delicate suturing process needed to connect donor corneal tissue to the patient’s native cornea and optically align it. The CorNeat KPro snaps into the patient’s trephined cornea and is then sutured to the eye using three non-degradable sutures. This process minimizes the time the eye is trephined and open (also known as “open sky”) to just a few minutes, significantly reducing the associated risks.
Regaining Sight
Watch the Moving Moment as Our First Patient Regains Sight After a Decade of Blindness
In January 2021, CorNeat achieved a significant milestone with the first implantation of the CorNeat KPro in Israel. Jamal, a 79-year-old man who had been blind for over a decade and had previously undergone four unsuccessful transplants, regained his sight and independence. Witness this heartwarming moment in a 2-minute news video that was broadcast on national TV stations worldwide.
Why CorNeat KPro ?
Optical Performance
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Equivalent to ideal cornea
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Wide field of view
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Enables intraocular procedures
Healing and Retention
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Immediate vision rehabilitation
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Permanently bio-integrates with the eye wall within weeks
Scalability
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Straightforward, 45-minute implantation
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Independent of eye banking and tissue availability
Safe
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No biologics - Safe to import/export
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Cannot carry any infectious agent including COVID-19
Q&A
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Would a person with severe dry eye be a candidate for the CorNeat KPro implantation?Initially we will treat patients with some tear production. With the accumulation of experience, we will collect the necessary evidence to encourage surgeons to tackle the most challenging and arid ophthalmic patients, suffering from alkali chemical burn, Stevens-Johnson Syndrome or ocular cicatricial pemphigus.
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Would a person with Stevens-Johnson Syndrome be a candidate for the CorNeat KPro implantation?See previous answer.
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Would a person with herpes keratitis be a candidate for the CorNeat KPro implantation?Yes, we believe that herpes keratitis patients stand to gain a valid therapeutic modality, which is currently missing in the battery of clinical ophthalmic solutions.
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Would a person with a scarred cornea be a candidate for the CorNeat KPro implantation?Scarred, opaque and/or vascularized corneas are excellent candidates for the CorNeat KPro.
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Would a person who had laser correction surgery be a candidate for the CorNeat KPro implantation?Yes, laser correction does not interfere with the CorNeat KPro implantation procedure.
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Would a person who had a corneal transplantation (one or more) which was/were rejected be a candidate for the CorNeat KPro implantation?Yes, patients with failed corneal grafts are our ideal candidates for implantation.
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What are the differences between the CorNeat KPro and the Boston KPro?The major differences between the two implants are i) The Boston KPro utilizes donor cornea tissue to attach the synthetic lens to the eye whereas the CorNeat KPro is completely synthetic eliminating the need for harvesting tissue to bridge the gap between the artificial lens and the patients eye. ii) The Boston KPro provides a narrow field of view both for the patient and the physician. This limits the ability of the practitioner to follow up on the eye’s health and intervene in time. Following implantation of the Boston KPro, access to the internal ocular compartments is blocked thus surgical procedures cannot be carried out. The CorNeat KPro is engineered with bays on the optic’s rim to enable anterior chamber access following implantation and will stay accessible throughout the patient’s life. Posterior chamber access is readily available through the device’s integrating element, which should stay accessible throughout life as well. This will also allow the ophthalmologist to perform regular and thorough follow-up and timely interventions as needed. The CorNeat KPro has a wide field of view similar to the native cornea providing the patient with real-life optics and restoring an aesthetic appearance. iii) The Boston KPro is a temporary solution, which needs to be replaced once every few years, when all goes well, or it permanently damages the eye's visual potential through a variety of complications. The CorNeat KPro is engineered to be a permanent solution with robust integration into the eye’s tissues.
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Where will the CorNeat KPro clinical trials take place?The CorNeat KPro clinical trial is taking place in Israel, Canada, France, the Netherlands and India and are planned to start in the USA in 2026.
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When will the CorNeat KPro be available for use?The CorNeat KPro launch is planned for 2027.
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What will the selection criteria be for patients for the CorNeat KPro implantation?Initially, the CorNeat KPro will be approved as a second-line treatment, only patients who lack a therapeutic alternative or have failed a corneal transplantation will be eligible for the procedure. Approval of the CorNeat KPro as a first-line treatment is a priority for CorNeat Vision and will follow the initial approval.
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Would a person with keratoconus be a candidate for the CorNeat KPro implantation?Keratoconus patients are suitable candidates for corneal transplantation with positive long-term results. Therefore, they are not ideal candidates for primary implantation. The CorNeat KPro is a viable solution in cases where a Keratoconus patient fails corneal transplantation for any reason, as a second-line treatment.
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Would a person with a detached retina be a candidate for the CorNeat KPro implantation?Such a patient would not be a good candidate as the CorNeat KPro mandates visual potential. Retinal issues, optic nerve function and other issues affecting visual potential need to be dealt with prior to attempting implantation of the CorNeat KPro.
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Would a person with glaucoma be a candidate for the CorNeat KPro implantation?Glaucoma is not a contraindication for the CorNeat KPro implantation. Glaucoma should be a consideration when planning the surgery as adjunct procedures, changes in drug regimen and visual potential might vary between glaucoma patients undergoing CorNeat KPro implantation. These factors impact eligibility and surgical and post-op planning.