EverMatrix™
Embedded For Life!
Domesticating the Foreign Body Response Around Implants
The Challange
Permanently Integrating Synthetic Materials with Living Tissue
When foreign materials enter the body, the immune system recognizes them as invaders and triggers a foreign body response. This involves inflammation and the formation of scar tissue around the material to isolate it. Over time, if the material is not absorbed or broken down, it remains encapsulated by this scar tissue. This means that nothing permanently integrates with soft tissue, as the body continuously tries to protect itself from the foreign object.
When developing implants, it's crucial to note that all implants, except those in immune-privileged sites like the eye or brain, trigger a chronic response. This was a significant challenge in creating our artificial cornea, which interfaces between the body and the external environment.
The need for a reliable and sealed interface led to the remarkable discovery of the EverMatrix™, a breakthrough that defied previous understanding of biomaterials.
The foreign body response is an immunological process that leads to the rejection and degradation of implanted devices and presents a fundamental challenge to their performance, durability, and therapeutic utility.
Our Technology
The CorNeat EverMatrix™, originally developed to permanently integrate a synthetic lens with resident ocular tissue, overcomes the main issue with implants and implantables – the foreign body response they trigger.
The EverMatrix™ seamlessly and permanently embeds with live tissue without triggering an inflammatory response. Its durability and flexibility, coupled with its bio-integration capabilities can significantly impact the safety and efficacy of implants across diversified fields of medicine and present an opportunity for new solutions that were not feasible before.
The EverMatrix™ is set to displace harvested and processed human and animal tissues, including scaffolds and extra cellular matrices, used in a variety of surgical procedures across diversified fields of medicine.
Use Cases
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Biomechanical attachment of implants to tissue
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Tissue repair & reinforcement
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Concealment of implants & sensors
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Guided Tissue & Bone Regeneration
Embedded For Life!
Tissue Integration
The features and benefits of the EverMatrix™ were proven histologically and clinically in various pre-clinical and clinical trials, and in several implantation sites. Findings demonstrate full fibroblast colonization and abundant collagen deposition with no encapsulation, rendering the EverMatrix™ an integral part of the surrounding tissue.
The following histology slides serve as good examples for the EverMatrix™ tissue-integration capabilities.
Osseo-Induction
Soft Tissue Integration
Soft Tissue Integration
H&E staining
Masson trichrome
Bone growth into device
EverMatrix™ Advantages
The CorNeat EverMatrix™ technology presents a paradigm shift in biomaterials as it uniquely combines permanency and tissue-integration capabilities. Unlike scaffolds, ECMs that are absorbed over time, the EverMatrix™ provides permanent support to the surrounding tissue, acting as "rebar mesh" enabling biomechanical integration of synthetic materials to living tissue.
Material properties:
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Non-degradable
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High tensile strength
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Flexible and durable
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High suture pullout force